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Updated: Jun 23, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
Published on: June 27, 2017
p65/RelA binds and activates the beclin 1 promoter
Tamara Copetti1, Francesca Demarchi, Claudio Schneider
1LNCIB Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie AREA Science Park, Trieste, Italy.
Abstract:
We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the binding of p65/RelA to the beclin 1 promoter accompanied by enhanced autophagy, suggesting that p65/RelA could regulate T-cell activation and homeostasis through autophagy.
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