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Related Experiment Video

Updated: Jun 23, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study.

Donna Brennan1, Mÿ G Mahoney

  • 1Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Cell Adhesion & Migration
|May 22, 2009
PubMed
Summary

Desmoglein 2 (Dsg2) is upregulated in many epithelial cancers, suggesting its potential as a novel diagnostic marker for these malignancies. Its expression varies with tumor type and differentiation status.

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Area of Science:

  • Cell adhesion
  • Cancer biology
  • Dermatology

Background:

  • Desmoglein 2 (Dsg2) is a desmosomal cadherin involved in cell-cell adhesion.
  • Dsg2 downregulation typically occurs with epithelial differentiation.
  • Dsg2 overexpression in keratinocytes promotes tumor-like behaviors.

Purpose of the Study:

  • To investigate the correlation between Dsg2 expression levels, localization, and tumor development.
  • To evaluate Dsg2 as a potential biomarker for epithelial malignancies.

Main Methods:

  • Generation and characterization of a novel Dsg2 antibody (Ab10).
  • Immunostaining of tissue microarrays using Ab10 and a previously established Dsg2 antibody (10D2).
  • Analysis of Dsg2 expression in various human epithelial and non-epithelial tumors.

Related Experiment Videos

Last Updated: Jun 23, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Main Results:

  • Dsg2 was significantly upregulated in basal cell carcinomas, squamous cell carcinomas, sebaceous/sweat gland carcinomas, and adenocarcinomas.
  • Dsg2 expression was absent in fibrosarcomas and melanomas.
  • Dsg2 expression was consistently strong in basal cell carcinomas and varied in squamous cell carcinomas, with a slight inverse correlation to tumor differentiation.

Conclusions:

  • Dsg2 is a potential novel marker for epithelial-derived malignancies.
  • Dsg2 expression patterns differ across various cancer types.
  • Further research is warranted to explore Dsg2's role in tumorigenesis and its clinical utility.