Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 23, 2026

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

Complexity in biomaterials for tissue engineering.

Elsie S Place1, Nicholas D Evans, Molly M Stevens

  • 1Department of Materials, Imperial College London, London SW7 2AZ, UK.

Nature Materials
|May 22, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same author

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Targeting bacterial influx pathways to defeat antibiotic resistance: fluorinated glucose-6-phosphate analogues revive fosfomycin efficacy.

npj antimicrobials and resistance·2026
Same author

Perfluorocarbon nanodroplets are cytocompatible with osteoblast-lineage cells and modulate in vitro osteoclastogenesis differentially in normoxia and hypoxia.

Scientific reports·2026
Same author

Bionano Interface Optimization for Rational Lateral Flow Assay Development.

ACS nano·2026
Same author

Image-guided optimization of regenerative graft attachment to the heart.

Biomaterials·2026
Same journal

Intranasal DNA nanocarrier vaccines with surface-patterned antigens enhance efficacy against respiratory syncytial virus.

Nature materials·2026
Same journal

An artificial neuromorphic interface for auditory restoration.

Nature materials·2026
Same journal

Seamless biointerfaces in devices.

Nature materials·2026
Same journal

Shaping the future of quantum technology.

Nature materials·2026
Same journal

Quantum tunnelling and leakage current across two-dimensional materials.

Nature materials·2026
Same journal

High-precision memristor-based computing.

Nature materials·2026
See all related articles

New biomaterials for tissue engineering are being developed using extracellular information. Simplified approaches aim to balance efficacy and cost-effectiveness for commercial success.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • The extracellular milieu provides critical molecular and physical cues for cellular behavior.
  • Existing cell-instructive scaffolds incorporate some extracellular influences, but many remain unexploited.
  • Commercial viability of tissue engineering products necessitates both efficacy and cost-effectiveness.

Purpose of the Study:

  • To explore the use of extracellular information in developing next-generation biomaterials for tissue engineering.
  • To investigate simplified strategies for recreating extracellular influences in biomaterials.
  • To address the dichotomy between sophisticated biomaterial design and ease of production.

Main Methods:

  • Analyzing molecular and physical information from the extracellular milieu.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

  • Developing cell-instructive scaffolds incorporating extracellular cues.
  • Simplifying biomaterial design by reducing biopolymers into functional domains.
  • Utilizing basic chemistries to guide cell fate.

    • Main Results:

    • Identification of key extracellular influences for biomaterial development.
    • Demonstration of simplified approaches to mimic extracellular signals.
    • Exploration of methods to reduce biopolymers into functional domains.
    • Application of basic chemistries for cell fate manipulation.

    Conclusions:

    • Simplified biomaterial designs can effectively recreate extracellular influences.
    • These developments can help reconcile clinical efficacy with commercial demands in tissue engineering.
    • Future research will focus on cost-effective and sophisticated biomaterial solutions.