Related Experiment Video
Updated: Jun 23, 2026
Preparation of the Rat Vocal Fold for Neuromuscular Analyses
Published on: May 15, 2020
Age-related blood flow changes in the rat intrinsic laryngeal muscles
Michael J Lyon1, Leslie T Malmgren
1Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA. lyonm@upstate.edu
Conclusions:
These results indicate that a deceased laryngeal blood flow (BF) could be one contributing factor to age-related phonatory and airway dysfunction.
Objective:
Studies of non-laryngeal muscles suggest that decreased BF may contribute to an age-related decline in muscle performance. We hypothesized that there is an age-related BF decrease to the intrinsic laryngeal muscles.
Materials And Methods:
Intrinsic laryngeal muscle BF was measured in young (3-6 months old; n=11) and old (28-30 months old; n=21) male Fischer 344 rats during quiet respiration using the radiolabeled microsphere technique.
Results:
BF to the posterior cricoarytenoid (PCA) was very high even during this submaximal recruitment, consistent with its specialization for oxidative metabolism and fatigue resistance. The results demonstrated significant (p<0.05) age-related BF decreases in the thyroarytenoid (young, 163; old, 64 ml/min/100 g), cricothyroid (young, 104; old, 52 ml/min/100 g), and PCA (young, 404; old, 235 ml/min/100 g).
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