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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Preparation, identification and thermodynamic stability of capsaicin-hydroxypropyl-beta-cyclodextrin inclusion
Xiaoyu Chen1, Zhirong Zhang, Ke Ren
1Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To prepare and identify the capsaicin-hydroxypropyl-beta-cyclodextrin (capsaicin-HP-beta-CD) inclusion compound the mol ratio between capsaicin and HP-beta-CD and the thermodynamic constants in inclusion were studied simultaneously.
Method:
The capsaicin-HP-beta-CD inclusion compound was prepared with the method of saturation aqueous solution. Meanwhile, the inclusion compound was identified by differential scanning calorimetry methods (DSC), infrared spectrometry (IR), and X-ray diffraction (XRD), respectively. The mol ratio between host and guest molecular and the thermodynamic constants during the inclusion process were also researched by phase solubility method.
Result:
An 1 : 1 molar ratio inclusion compound of capsaicin with HP-beta-CD could form at 25, 35 and 45 degrees C. The phase diagram was A(L) type.
Conclusion:
The solubility of capsaicin-HP-beta-CD inclusion compound can be increased obviously.
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