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Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
The Supercomplexes in the Crista Membrane01:41

The Supercomplexes in the Crista Membrane

The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
Nitrosation of Enols01:19

Nitrosation of Enols

The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.

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Related Experiment Video

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Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
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Dinitrosyl iron complexes relevant to Rieske cluster nitrosylation.

Zachary J Tonzetich1, Loi H Do, Stephen J Lippard

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society
|May 23, 2009
PubMed
Summary

The reaction of a Rieske cluster model with nitric oxide disassembles the iron-sulfur core, forming dinitrosyliron complexes (DNICs). New neutral and reduced DNICs were synthesized, offering rare redox-partner examples.

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Area of Science:

  • Bioinorganic Chemistry
  • Coordination Chemistry
  • Nitric Oxide Chemistry

Background:

  • Rieske clusters are vital iron-sulfur proteins.
  • Nitric oxide (NO) plays diverse biological roles.
  • Dinitrosyliron complexes (DNICs) are implicated in NO signaling.

Purpose of the Study:

  • To investigate the reaction of a synthetic Rieske cluster model with nitric oxide.
  • To synthesize and characterize novel dinitrosyliron complexes (DNICs).
  • To explore the redox behavior of DNICs in a nitrogen-rich environment.

Main Methods:

  • Reaction of a specific iron-sulfur cluster model with nitric oxide.
  • Isolation and characterization of dinitrosyliron complexes (DNICs) using techniques like X-ray crystallography (implied).
  • Synthesis and electrochemical reduction of a novel beta-diketiminate-ligated DNIC.

Main Results:

  • Nitric oxide induced the disassembly of the iron-sulfur core, forming dinitrosyliron complexes (DNICs).
  • A new DNIC, (Et(4)N)[(N(2)CHPh)Fe(NO)(2)], was isolated and characterized.
  • A neutral {Fe(NO)(2)}(9) DNIC with a beta-diketiminate ligand was synthesized, and its one-electron reduction yielded an isolable {Fe(NO)(2)}(10) DNIC.

Conclusions:

  • The synthetic Rieske cluster model shows homology with purely thiolate-bound Fe(2)S(2) clusters in NO reactions.
  • Structurally analogous DNIC redox partners were prepared, representing a rare example.
  • These findings advance the understanding of iron-sulfur cluster reactivity and dinitrosyliron complex chemistry.