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Updated: Jun 23, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
The ten commandments of pain assessment and management in preterm neonates
Marlene Walden1, Carol Carrier
1School of Nursing, The University of Texas, 1700 Red River, Mailcode D0100, Austin, TX 78701-1499, USA. mwaldennnp@aol.com
Insights
Effective pain management for preterm neonates is crucial. This study presents guidelines to improve the use of nonpharmacologic and pharmacologic therapies for pain relief in the neonatal intensive care unit (NICU).
Area of Science:
- Neonatal care
- Pain management
- Evidence-based practice
Background:
- Advances in pain assessment and management for preterm neonates remain underutilized.
- Untreated pain in neonates can lead to lifelong physiological and psychological consequences.
- Painful procedures in the neonatal intensive care unit (NICU) are often unavoidable.
Observation:
- Nonpharmacologic and pharmacologic analgesic therapies are underused for acute and procedural pain in preterm infants.
- The long-term effects of untreated pain in neonates are significant.
- Caregivers must balance necessary medical interventions with effective pain relief strategies.
Findings:
- Evidence-based nonpharmacologic and pharmacologic strategies are vital for managing pain and stress in neonates.
- The "Ten Commandments of pain assessment and management in preterm neonates" are presented.
- These guidelines aim to promote best practices and compassionate care.
Implications:
- Implementing these guidelines can improve pain management outcomes for preterm infants.
- Enhanced pain management may reduce the lifelong physiologic and psychological consequences of untreated pain.
- Promoting compassionate care in the NICU is essential for neonate well-being.
Abstract:
Despite advances in pain assessment and management, nonpharmacologic and pharmacologic analgesic therapies continue to be underutilized in managing both acute and procedural pain in preterm neonates. Untreated acute, recurrent, or chronic pain related to disease or medical care may have significant and lifelong physiologic and psychological consequences. Painful procedures in the NICU may be unavoidable, so it is vital that caregivers balance the painful, medically necessary care with evidence-based nonpharmacologic and pharmacologic strategies to relieve pain and stress. We present Ten Commandments of pain assessment and management in preterm neonates to promote the use of best practices and compassionate care in the NICU.
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