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Updated: Jan 31, 2026
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
[Protective effect of estrogen against chemotherapy-induced ovarian damage in rats]
1Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. hanliping.2006@yahoo.com.cn
Objective:
To investigate the protective effect of estrogen against cyclophosphamide (CTX)-induced ovarian failure in female rats.
Methods:
Sixty female Wistar rats (2-3 months old) were randomized into 4 groups to receive treatments with normal saline, CTX, estradiol (E2) or CTX+E2. Serum estradiol and follicle-stimulating hormone (FSH) concentrations were measured regularly in the 4 groups, and the weight of the ovary and uterus, follicle number and mean diameter of the follicles were compared.
Results:
Compared with CTX+EE2 group, the CTX group showed significantly increased FSH levels and decreased EE2 levels (P<0.05). The weight of the ovary and uterus and follicle number were significantly lower in CTX group than in CTX+EE2 group (P<0.05). No obvious differences in the indexes were found between the control and CTX+E2 groups.
Conclusion:
Estrogen administration provides protection against CTX-induced ovarian damage in rats.
