Related Experiment Video
Updated: Jun 23, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
[Changes in oral microflora in patients with recurrent oral ulcers]
Jian-Zhang Wang1, Qing Chen, Hong Shen
1Department of Pathology, Southern Medical University, Guangzhou 510515, China. setbobo@126.com
Objective:
To investigate the correlation between the changes in oral microflora and recurrent oral ulcers (ROU).
Methods:
Salivary sample were collected from ROU patients with oral ulcers (group T) and those with ulcer healing (group C) as well as from ROU-free individuals (group N). The quantity of 3 common bacteria (Streptococcus sp., Veillonella sp., and Neisseria sp.) in the salivary samples was detected and compared between the 3 groups.
Results:
The quantities of Streptococcus sp. (7.30-/+0.89 copies/ml) and Veillonella sp. (8.29-/+0.77 copies/ml) in group T were significantly lower than those in group N (8.15-/+0.55 and 8.93-/+0.76 copies/ml, respectively, P<0.01), but similar with those in group C. The quantity of Streptococcus sp. (7.51-/+0.81 copies/ml) in group C was significantly lower than that in group N (8.15-/+0.55 copies/ml, P<0.01), but the quantity of Veillonella sp. was similar between the two groups. No significant difference were found in the quantity of Neisseria sp. between the 3 groups.
Conclusion:
The quantity of oral microflora differs significantly between patients with recurrent oral ulcers and normal individuals, suggesting a possible correlation between oral microfora and recurrent oral ulcers.
Related Concept Videos
The Oral Microbiota
Development of the Oral Microbiota
Microbiota of the Stomach and Small Intestine
Microbiota Modulation by Antibiotics
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease II: Pathophysiology

