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Related Experiment Video

Updated: Jun 23, 2026

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography.

M Yogarajah1, N K Focke, S Bonelli

  • 1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK. j.duncan@ion.ucl.ac.uk

Brain : a Journal of Neurology
|May 23, 2009
PubMed
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Anterior temporal lobe resection can cause visual field deficits due to variable Meyer's loop anatomy. Diffusion tensor tractography helps predict these deficits, aiding surgical planning for optic radiation preservation.

Area of Science:

  • Neuroimaging
  • Neurosurgery
  • Ophthalmology

Background:

  • Anterior temporal lobe resection (ATLR) frequently results in visual field deficits (VFDs), impacting patient quality of life.
  • These VFDs stem from damage to Meyer's loop, a part of the optic radiation with unpredictable anterior extension on standard MRI.
  • The variability of Meyer's loop makes it challenging to anticipate and mitigate VFDs during ATLR.

Purpose of the Study:

  • To investigate the anatomical variability of Meyer's loop using diffusion tensor tractography (DTT).
  • To correlate Meyer's loop anatomy and temporal lobe resection size with the severity of postoperative superior quadrantic VFDs.
  • To evaluate DTT's utility in predicting VFD risk after ATLR.

Main Methods:

  • Diffusion tensor tractography (DTT) was employed to map the optic radiation, specifically Meyer's loop, in 20 controls and 21 patients undergoing ATLR.

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Last Updated: Jun 23, 2026

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
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  • The anterior extent of Meyer's loop was quantified by measuring its distance to the temporal pole and temporal horn.
  • Postoperative visual fields were assessed using Goldmann perimetry, and resection volumes were measured from T1-weighted MRI scans.

    • Main Results:

    • Significant VFDs (22%–87%) were observed in 9 patients post-ATLR.
    • Linear regression analysis revealed that both the distance from Meyer's loop tip to the temporal pole and the resection volume were significant predictors of VFD severity.
    • Anatomical measurements of Meyer's loop in patients and controls showed considerable variation.

    Conclusions:

    • There is substantial individual variation in the anterior extent of Meyer's loop.
    • DTT is a valuable tool for assessing the anterior extent of Meyer's loop and predicting VFD risk following ATLR.
    • This technique can aid in surgical planning to minimize optic radiation damage and subsequent visual field loss.