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Related Experiment Video

Updated: Jun 23, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

The SOS response controls integron recombination.

Emilie Guerin¹, Guillaume Cambray, Neus Sanchez-Alberola

¹Université de Limoges, Faculté de Médecine, EA3175, INSERM, Equipe Avenir, 87000 Limoges, France.

Science (New York, N.Y.)

|May 23, 2009

Summary

This summary is machine-generated.

Integrons, key in antibiotic resistance spread, are linked to the bacterial SOS response. This connection helps bacteria adapt by controlling gene cassette swapping under stress, impacting antibiotic treatment strategies.

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Last Updated: Jun 23, 2026

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

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Published on: June 19, 2015

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

Area of Science:

Microbiology
Genetics
Molecular Biology

Background:

Integrons are genetic platforms prevalent in environmental bacteria.
They are primarily recognized for facilitating the dissemination of antibiotic resistance genes among Gram-negative pathogens.

Purpose of the Study:

To investigate the relationship between integron systems and the bacterial SOS response.
To understand how this interaction influences the regulation of integron integrases and cassette recombination.

Main Methods:

Analysis of gene expression data.
Investigating the regulatory control of integron integrases by LexA.
Assessing the impact of cellular stress on integron-mediated recombination.

Main Results:

A direct link was established between the SOS response and integron activity.
LexA was identified as a key regulator controlling the expression of most integron integrases.
This regulatory coupling enhances cassette capture under stress conditions and minimizes rearrangements in stable environments.

Conclusions:

Integrons function as integrated adaptive systems, responding to environmental cues.
The interplay between integrons and the SOS response has significant implications for understanding and combating antibiotic resistance.
This discovery may inform future antibiotic treatment policies.