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Related Experiment Video

Updated: Jun 23, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

p16 expression in conventional and desmoplastic trichilemmomas.

Nicholaus J Hilliard1, Dara N Wakefield, Dieter Krahl

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0009, USA.

The American Journal of Dermatopathology
|May 23, 2009
PubMed
Summary

p16 expression is common in trichilemmomas, both conventional and desmoplastic types. This study investigates p16

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Area of Science:

  • Dermatopathology
  • Oncology
  • Molecular Biology

Background:

  • p16 expression is elevated in various skin cancers, including those linked to UV radiation and human papillomavirus (HPV).
  • p16 is a validated surrogate marker for HPV presence in cervical dysplasia and tonsillar carcinoma.
  • The role of p16 in trichilemmomas, a type of skin neoplasm, requires further investigation.

Purpose of the Study:

  • To investigate and characterize the expression pattern of p16 in conventional and desmoplastic trichilemmomas.
  • To compare p16 expression in trichilemmomas with its known expression in other cutaneous neoplasms.
  • To critically evaluate the potential relationship between p16 expression and HPV infection in trichilemmomas.

Main Methods:

  • Immunohistochemical staining for p16 was performed on 26 conventional and 19 desmoplastic trichilemmomas.

Related Experiment Videos

Last Updated: Jun 23, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

  • The pattern (nuclear and cytoplasmic) and intensity of p16 staining were analyzed.
  • Findings were compared with existing literature on p16 expression in other skin neoplasms.

    • Main Results:

    • p16 immunostaining was observed in the majority of conventional trichilemmomas (80.8%) and desmoplastic trichilemmomas (73.7%).
    • The staining exhibited both nuclear and cytoplasmic localization.
    • A more pronounced staining intensity was noted in the desmoplastic variant compared to the conventional type.

    Conclusions:

    • This study is the first to report p16 expression in trichilemmomas.
    • The findings suggest a significant presence of p16 in these neoplasms, with variations between subtypes.
    • Further research is warranted to elucidate the specific role of p16 and its potential link to HPV in trichilemmoma development.