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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Alternative splicing in lung cancer.

Ruben Pio1, Luis M Montuenga

  • 1Division of Oncology, Center for Applied Medical Research and School of Medicine, University of Navarra, Pamplona, Spain. rpio@unav.es

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
|May 23, 2009
PubMed
Summary

Alternative splicing alterations are crucial in lung cancer development. Understanding these changes, like Bcl-xL/Bcl-xS balance shifts and splicing factor abnormalities, offers new diagnostic and therapeutic targets.

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Alternative splicing is a key regulator of gene expression impacting biological processes.
  • Dysregulation of alternative splicing is implicated in various pathologies, notably cancer.
  • Lung cancer exhibits significant alterations in alternative splicing patterns.

Purpose of the Study:

  • To review the evidence linking alternative splicing to lung cancer.
  • To highlight specific examples of splicing alterations in lung cancer.
  • To discuss the potential of alternative splicing as a diagnostic and therapeutic target.

Main Methods:

  • Literature review of studies on alternative splicing in lung cancer.
  • Analysis of specific splicing events, such as Bcl-xL and Bcl-xS.
  • Examination of altered expression of splicing regulatory factors in lung tumors.

Main Results:

  • Alternative splicing dysregulation is a hallmark of lung cancer.
  • The balance between Bcl-xL and Bcl-xS splice variants is altered in lung cancer.
  • Abnormal expression of splicing regulators (e.g., ASF/SF2, hnRNPs) is observed in lung tumors.

Conclusions:

  • Alternative splicing plays a critical role in lung cancer pathogenesis.
  • Targeting aberrant alternative splicing pathways presents a promising avenue for lung cancer diagnosis and treatment.