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Updated: Jun 23, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Bowel resection induced intestinal adaptation: progress from bench to bedside.

S W Longshore¹, D Wakeman, M McMellen

¹Division of Pediatric Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO 63110, USA.

Minerva Pediatrica

|May 23, 2009

Summary

Massive short bowel resection (SBR) triggers intestinal adaptation, enhancing structure and function to aid nutrient absorption. Understanding these adaptive mechanisms is crucial for developing life-saving therapies.

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Tissue Engineering of the Intestine in a Murine Model

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Published on: December 1, 2012

Area of Science:

Gastroenterology
Cell Biology
Surgical Research

Background:

Massive short bowel resection (SBR) necessitates significant intestinal adaptation for survival.
Inadequate adaptation leads to parenteral nutrition dependence and liver dysfunction.

Purpose of the Study:

To elucidate the structural and functional mechanisms of intestinal adaptation post-SBR.
To identify key mediators driving adaptive responses in the remnant intestine.

Main Methods:

The study reviews structural changes (e.g., increased weight, villus height, crypt depth) and functional alterations (e.g., transporter upregulation) following SBR.
It discusses the role of proliferative stimuli and cellular progression along the crypt-villus axis.

Main Results:

Intestinal adaptation involves increased wet weight, protein, DNA, villus height, crypt depth, and absorptive surface area.
Functional adaptation includes upregulation of nutrient transporters and digestive enzymes.
Key mediators like nutrients, hormones, and growth factors influence adaptation.

Conclusions:

Intestinal adaptation is a critical physiological process compensating for lost digestive and absorptive capacity after SBR.
Understanding adaptation mechanisms is vital for developing novel therapies to improve patient outcomes and reduce parenteral nutrition dependence.