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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Targeted Cancer Therapies02:57

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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miR-10 in development and cancer.

A H Lund1

  • 1Biotech Research and Innovation Centre and Center for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark. anders.lund@bric.dk

Cell Death and Differentiation
|May 23, 2009
PubMed
Summary
This summary is machine-generated.

The microRNA (miRNA) miR-10 family, crucial in development and cancer, has a newly discovered role. Beyond repressing translation, miR-10 can now enhance the translation of specific messenger RNAs (mRNAs) with a terminal oligo-pyrimidine motif.

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • The microRNA (miRNA) miR-10 family is highly conserved and located within Hox gene clusters, which are key developmental regulators.
  • miR-10 is coexpressed with Hox genes and known to regulate their transcript translation.
  • Dysregulation of miR-10 family members is implicated in various cancers.

Purpose of the Study:

  • To investigate the multifaceted roles of the miR-10 family in gene regulation.
  • To explore the recently identified function of miR-10 in translational activation.

Main Methods:

  • Bioinformatic analysis of miRNA and mRNA interactions.
  • Experimental validation of miRNA binding and translational effects.
  • Analysis of terminal oligo-pyrimidine (TOP) motif containing transcripts.

Main Results:

  • miR-10 family members are confirmed regulators of Hox gene expression.
  • A novel function for miR-10 in inducing translation of specific transcripts was identified.
  • This translational induction is linked to the presence of a terminal oligo-pyrimidine (TOP) motif.

Conclusions:

  • The miR-10 family exhibits a dual role in gene expression, acting as both a translational repressor and activator.
  • The discovery of miR-10's role in TOP motif transcript translation expands our understanding of miRNA regulatory mechanisms.
  • This finding has implications for understanding development and cancer biology.