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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Related Experiment Video

Updated: Jun 23, 2026

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
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Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.

Prabodhika Mallikaratchy1, Haipeng Liu, Yu Fen Huang

  • 1Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.

Chemical Communications (Cambridge, England)
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Summary

We developed a modified Sgc8 aptamer construct that can release molecules on tumor surfaces. This novel approach uses DNA template assisted functional group transfer reactions for targeted drug delivery.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nanotechnology

Background:

  • Aptamers are short DNA or RNA molecules that can bind to specific targets.
  • Targeted drug delivery aims to increase drug efficacy and reduce side effects.
  • Stimulated molecular release at tumor sites requires precise control mechanisms.

Purpose of the Study:

  • To develop a chemically modified aptamer construct for targeted drug delivery.
  • To enable stimulated release of molecules at the tumor surface.
  • To utilize DNA template assisted functional group transfer reactions (DTGTR) for controlled molecular release.

Main Methods:

  • Selection of the Sgc8 aptamer against CEM cells.
  • Chemical modification of the Sgc8 aptamer.
  • Conjugation of the modified aptamer to an activator platform.
  • Application of DNA template assisted functional group transfer reactions (DTGTR) for molecule release.

Main Results:

  • A functional aptamer construct was successfully synthesized.
  • The construct demonstrated specific binding to CEM cells.
  • Stimulated release of molecules at the tumor surface was achieved using DTGTR.

Conclusions:

  • The chemically modified Sgc8 aptamer construct is a promising platform for targeted drug delivery.
  • DTGTR offers a novel method for controlled molecular release at tumor sites.
  • This approach has potential for improving cancer therapy efficacy.