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Published on: February 28, 2025
[Sedation and analgesia in neonatology.]
Yerkes Pereira E Silva1, Renato Santiago Gomez, Thadeu Alves Máximo
1Hospital Life Center, Belo Horizonte, MG.
Insights
Minimizing pain and stress in newborns is crucial. This review covers pain prevention, non-pharmacological and pharmacological treatments, and sedation strategies for neonates.
Area of Science:
- Neonatology
- Pediatric Pain Management
Context:
- Pain and stress cause significant suffering in newborns.
- Neonatal Intensive Care Units (NICUs) require strategies to humanize care and reduce patient/family stress.
- Limited interventions have historically addressed neonatal pain and discomfort.
Purpose:
- To review methods for preventing pain in newborns.
- To discuss non-pharmacological and pharmacological pain treatments for neonates.
- To outline sedation approaches for newborns, including drug classes.
Summary:
- Non-pharmacological pain prevention in NICUs includes measures like non-nutritive suckling and glucose administration.
- Pharmacological pain management involves non-opioid analgesics, opioids, and local anesthetics.
- Sedation for newborns utilizes medications such as chloral hydrate, barbiturates, propofol, and benzodiazepines to manage agitation.
Impact:
- Individualized pain prevention and analgesia are essential for all newborns undergoing potentially painful procedures.
- Effective pain management in neonates can reduce suffering and improve outcomes.
- This review provides a comprehensive overview of current strategies for neonatal pain and sedation.
Background And Objectives:
The study of pain in neonatology is important because pain and stress mean suffering and discomfort for newborns and, despite it, very little has been done to minimize them. In this revision we discuss: prevention of pain, non-pharmacological and pharmacological treatment, and sedation in newborns.
Contents:
Several non-pharmacological measures can be taken to prevent pain in Neonatal Intensive Care Units, and to humanize and reduce the stress on the environment for patients and their families. Pain treatment in the newborn consists of non-pharmacological (non-nutritive suckling, glucose) and pharmacological (non-opioid analgesics, opioids, and local anesthetics) measures. Sedation in the newborn is achieved with drugs that decrease activity, anxiety, and agitation of the patient, and that could lead to amnesia of painful and non-painful events. Sedation can be accomplished with chloral hydrate, barbiturates, propofol, and benzodiazepines.
Conclusions:
Prevention of pain and the indication of analgesia should be individualized and always considered in every newborn with potentially painful disorders and/or undergoing invasive procedures, surgical or not.
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