[Data on methods in methacholine inhalation provocation tests (dose-response relationship)]
Related Experiment Video
Updated: Apr 22, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
1III. Med. Klinik-Schwerpunkt Pneumologie, Univ.-Klinik Mainz.
Abstract:
The cholinergic agonist Methacholine is widely used in unspecific inhalation provocation tests. The maximum changes in lung function take place within two minutes after inhalation. The following spontaneous regression of bronchoconstriction to baseline is prolonged. Therefore, cumulative dose response curves are possible to do. The results of those tests are very dependent on the methods used. Strict standardization of the individual method is necessary. One possible inhalation provocation technique is described.
Related Concept Videos
Dose-Response Relationship: Overview
Dose-Response Relationship: Potency and Efficacy
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

