Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stages of General Anesthesia

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...

General Anesthesia: Overview

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

Inhalational Anesthetics: Overview

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A key...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024

Same author

Single-Nucleotide Polymorphisms of the <i>PAR2</i> and <i>IL-17A</i> Genes Are Significantly Associated with Chronic Pain.

International journal of molecular sciences·2023

Same author

Effects and Limitations of Naldemedine for Opioid-Induced Urinary Retention: A Case Report.

Journal of palliative medicine·2023

Same author

Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (<i>TRPC3</i>) Gene Is Associated with Chronic Pain.

International journal of molecular sciences·2023

Same author

Lower leg blood pressure decreases while calf external pressure increases with the angulation of the Trendelenburg position in the lithotomy position with calf- and foot-supported leg holders.

Journal of robotic surgery·2022

Same author

Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories.

Journal of applied toxicology : JAT·2022

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

[Isorhythmic dissociation during sevoflurane anesthesia].

Ju Mizuno¹, Shigeho Morita, Kohei Kamiya

¹Department of Anesthesiology, Teikyo University School of Medicine, Tokyo 173-8605.

Masui. the Japanese Journal of Anesthesiology

|May 26, 2009

Summary

Sevoflurane anesthesia can cause atrioventricular junctional rhythm (AVJR), a type of heart rhythm disturbance. This condition, known as isorhythmic dissociation, may lead to hypotension during surgery.

More Related Videos

Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice

Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice

Published on: October 11, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice

Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice

Published on: October 11, 2024

Area of Science:

Anesthesiology
Cardiology

Background:

General anesthesia, particularly with inhalation agents, can occasionally affect cardiac conduction.
Atrioventricular junctional rhythm (AVJR) is a potential complication during anesthesia.

Observation:

A case of AVJR during sevoflurane maintenance anesthesia in a 61-year-old woman undergoing knee arthroplasty.
Electrocardiogram showed dissociated P-waves approaching, entering, and exiting QRS complexes, with transient ST depression.

Findings:

The phenomenon was diagnosed as AVJR with isorhythmic dissociation.
Discontinuation of sevoflurane resolved the isorhythmic dissociation, restoring sinus rhythm.

Implications:

Sevoflurane can induce atrioventricular conduction disturbances leading to isorhythmic dissociation and AVJR.
Clinicians should be aware of the potential for hypotension associated with isorhythmic dissociation during sevoflurane anesthesia.