[Morphological prerequisites of heart ventricles fibrillation in sudden cardiac death]

Area of Science:

• Cardiovascular Pathology
• Sudden Cardiac Death Etiology
• Myocardial Infarction

Background:

• Out-of-hospital sudden death is often linked to acute coronary insufficiency and myocardial infarction.
• Understanding the morphological basis of sudden cardiac death is crucial for prevention and treatment.
• Electrolyte imbalances may play a role in cardiac events.

Purpose of the Study:

• To investigate morphological changes in the myocardium.
• To analyze the content of glucose, magnesium, calcium, and sodium in pericardial fluid.
• To determine the relationship between these factors and sudden cardiac death in acute coronary insufficiency and pre-infarction stages.

Main Methods:

• Histopathological examination of myocardial tissue from sudden cardiac death victims.
• Biochemical analysis of pericardial fluid for glucose, magnesium, calcium, and sodium levels.
• Correlation of morphological findings with clinical data.

Main Results:

• Significant morphological changes observed in the myocardium, including contracture lesions (III degree) and myocytolysis.
• Myocardium in both ischemic and relaxation zones lost contractile properties, leading to asynchronous ventricular contractions.
• Simultaneous fibrillation in both ventricles suggests a common morphological origin.

Conclusions:

• Areas of ischemic injury and relaxation in the myocardium are identified as the morphological prerequisite for ventricular fibrillation.
• Myocardial dysfunction, characterized by loss of contractile properties, is a key factor in sudden cardiac death.
• Electrolyte analysis in pericardial fluid may offer insights into the pathophysiology of sudden cardiac events.