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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
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Peptic Ulcer Disease IV: Management01:26

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Asthma: Pathogenesis and Management01:20

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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Eosinophilic esophagitis: pathophysiology and optimal management.

Carol Garrean1, Ikuo Hirano

  • 1Division of Gastroenterology and Hepatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

Current Gastroenterology Reports
|May 26, 2009
PubMed
Summary

Eosinophilic esophagitis (EoE) is a growing condition causing esophageal issues and eosinophil buildup. Research is exploring its causes, including allergies and immune factors, and effective treatments like diets and medications.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic esophagitis (EoE) is an increasingly recognized immune-mediated esophageal disease.
  • Characterized by esophageal symptoms and eosinophilic infiltration of the esophageal mucosa.
  • Rising prevalence and complex pathogenesis are under active investigation.

Purpose of the Study:

  • To review the current understanding of EoE pathogenesis.
  • To discuss the evolving and controversial management strategies for EoE.
  • To highlight various therapeutic options available for EoE patients.

Main Methods:

  • Literature review of recent studies on EoE.
  • Analysis of factors contributing to EoE prevalence and pathogenesis.
  • Summary of current and emerging treatment modalities.

Main Results:

  • Food and environmental allergies, host immune factors, and GERD interactions are key aspects of EoE.
  • Medical therapies (acid suppression, corticosteroids, biologics), elimination diets, and dilation are effective.
  • Management is individualized, ranging from observation to multimodal approaches.

Conclusions:

  • EoE is a significant condition with multifactorial causes.
  • Optimal management requires a personalized approach considering diverse therapeutic options.
  • Continued research is crucial for advancing EoE understanding and treatment.