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Updated: Jun 22, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
09:04

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Correlates of adverse events during saphenous vein graft intervention with distal embolic protection: a PRIDE

Ajay J Kirtane1, Eugene R Heyman, Christopher Metzger

  • 1Center for Interventional Vascular Therapy, Columbia University Medical Center, New York, New York, USA.

JACC. Cardiovascular Interventions
|May 26, 2009
PubMed

Insights

Longer lesion length in saphenous vein grafts (SVGs) is the primary predictor of adverse events after percutaneous coronary intervention (PCI). This finding holds true even for relatively short lesions, highlighting the importance of lesion length in PCI outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Major adverse cardiac events (MACE) remain a concern for patients undergoing saphenous vein graft (SVG) intervention, despite the use of distal embolic protection devices.
  • Predictors of MACE in this patient group are not well-defined, necessitating further investigation.

Purpose of the Study:

  • To identify correlates of 30-day adverse events in patients undergoing percutaneous coronary intervention (PCI) of SVGs.
  • To characterize major predictors of MACE among patients undergoing SVG intervention with distal embolic protection.

Main Methods:

  • Analysis of 631 patients from the PRIDE study undergoing SVG intervention with distal embolic protection.
  • Assessment of correlates for 30-day MACE and peri-procedural creatine kinase-myocardial band (CK-MB) elevation.
  • Comparison of TriActiv System against active control devices (Guardwire or Filterwire).

Main Results:

  • Longer lesion length, greater plaque volume, and higher SVG degeneration score were associated with MACE.
  • Angiographic lesion length was the strongest independent correlate of MACE (OR 2.81) and CK-MB elevation (OR 2.54).
  • A graded increase in MACE was observed with increasing lesion lengths, consistent across different embolic protection devices.

Conclusions:

  • Angiographic lesion length is the most significant correlate of short-term adverse events in SVG intervention with distal embolic protection.
  • Adverse event risk increases incrementally with lesion length, even at shorter lengths.
  • These findings emphasize the critical role of lesion length in predicting outcomes during SVG PCI.
Abstract

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