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Updated: Jun 22, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
Use of CoSeal in a patient with a left ventricular assist device
Aldo Cannata1, Corrado Taglieri, Claudio F Russo
1Angelo De Gasperis Department of Cardiac Surgery, Niguarda Ca' Granda Hospital, Milan, Italy. aldo.cannata@ospedaleniguarda.it
Insights
CoSeal surgical sealant may reduce adhesions after left-ventricular assist device implantation. This facilitates future cardiac surgeries, potentially improving patient outcomes in heart failure management.
Area of Science:
- Cardiology
- Surgical Innovation
Background:
- Idiopathic dilated cardiomyopathy presents significant challenges in heart failure management.
- Patients may require advanced interventions like left-ventricular assist devices (LVADs) and heart transplantation.
- Previous cardiac surgeries can lead to adhesion formation, complicating subsequent procedures.
Observation:
- A patient with end-stage cardiomyopathy received an LVAD with CoSeal surgical sealant applied to the cardiac surface.
- During a subsequent heart transplant re-sternotomy, dissection around the LVAD was notably easier.
- Avascular, loose adhesions were observed, contrasting with typical post-surgical scarring.
Findings:
- CoSeal surgical sealant application appeared to inhibit the formation of dense adhesions.
- The reduced adhesion facilitated the surgical dissection during the heart transplantation procedure.
- This suggests a potential benefit of CoSeal in managing adhesions post-LVAD implantation.
Implications:
- CoSeal may be a valuable tool for mitigating post-operative adhesions in cardiac surgery.
- Reduced adhesions can simplify complex procedures like LVAD explantation and heart transplantation.
- Further clinical studies are needed to confirm the efficacy and safety of CoSeal for adhesion inhibition in this context.
Abstract:
A 45-year-old man with end-stage idiopathic dilatated cardiomyopathy had previously undergone two left anterolateral thoracotomies for implantation and explantation of a left ventricular epicardial lead for biventricular pacing. Because of worsening heart failure and a predicted long delay to heart transplantation, a left-ventricular assist device was implanted, with application of CoSeal surgical sealant (Baxter Healthcare Corp, Fremont, CA) on the cardiac surface. At re-sternotomy for heart transplantation, surgical dissection of the left-ventricular assist device was greatly facilitated by the presence of avascular, very loose adhesions. CoSeal (Baxter Healthcare Corp) seems to be useful for the inhibition of adhesion formation after left-ventricular assist device implantation, although further clinical experience with this approach is required.
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