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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

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Related Experiment Video

Updated: Jun 22, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

Complement component 5a (C5a).

Helga D Manthey1, Trent M Woodruff, Stephen M Taylor

  • 1School of Biomedical Sciences, University of Queensland, Brisbane, Australia. h.manthey@uq.edu.au

The International Journal of Biochemistry & Cell Biology
|May 26, 2009
PubMed
Summary
This summary is machine-generated.

Complement component 5a (C5a) is a pro-inflammatory mediator involved in innate immunity. Its role via the C5L2 receptor is unclear, but C5a inhibition is a promising therapeutic strategy for inflammatory diseases.

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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

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Last Updated: Jun 22, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Complement component 5a (C5a) is a potent pro-inflammatory mediator derived from C5 during complement cascade activation.
  • C5a exerts effects through the G protein-coupled receptor CD88 and the less understood C5L2 receptor.
  • Widespread C5a receptor expression contributes to its broad physiological effects.

Purpose of the Study:

  • To elucidate the roles of C5a and its metabolite C5adesArg.
  • To investigate the functions of C5a and C5adesArg at the C5L2 receptor.
  • To highlight the therapeutic potential of C5a inhibition in immuno-inflammatory diseases.

Main Methods:

  • Enzymatic cleavage of C5 to C5a.
  • Metabolism of C5a to C5adesArg by carboxypeptidases.
  • Receptor binding and signaling studies via CD88 and C5L2.

Main Results:

  • C5a is a key mediator in innate immune responses.
  • C5a and C5adesArg signal through CD88.
  • The precise actions of C5a and C5adesArg at C5L2 require further investigation.

Conclusions:

  • C5a is a significant driver of pathogenesis in various immuno-inflammatory diseases.
  • Targeting C5a represents a viable therapeutic approach.
  • Further research into C5L2-mediated C5a actions is warranted.