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Neonatal stress modulates sickness behavior.

Ronit Avitsur1, John F Sheridan

  • 1School of Behavioral Sciences, The Academic College of Tel Aviv-Yaffo, Yaffo 68114, Israel. avitsur@mta.ac.il

Brain, Behavior, and Immunity
|May 26, 2009
PubMed
Summary
This summary is machine-generated.

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Early life stress, such as maternal separation, can permanently alter adult responses to illness. Neonatal stress in mice led to heightened sickness behaviors and immune responses throughout their lives.

Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Psychology

Background:

  • Early life environment critically shapes adult stress resilience and disease susceptibility.
  • Neonatal stress has been previously shown to increase inflammatory responses and viral load in adult mice.

Purpose of the Study:

  • To investigate the long-term impact of neonatal stress on adult behavioral and immunological responses to immune challenges.
  • To determine if maternal separation stress during development affects adult sickness behavior.

Main Methods:

  • Mouse pups underwent maternal separation (MSP) daily or for extended periods during specific neonatal developmental windows.
  • Adult mice exposed to neonatal MSP were subsequently challenged with influenza virus infection or lipopolysaccharide (LPS) injection.

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  • Sickness behaviors, including body weight changes and consumption of food and sweet solutions, were monitored post-challenge.

    • Main Results:

    • Neonatal stress exposure resulted in accelerated and intensified sickness behaviors following immune activation.
    • Adult mice with a history of neonatal stress exhibited augmented behavioral and immunological responses to influenza and LPS challenges.
    • These effects persisted throughout adulthood, indicating long-lasting alterations.

    Conclusions:

    • Neonatal stress disrupts the regulation of innate immunity, leading to exaggerated responses to immune challenges.
    • Early life stress can establish long-lasting individual differences in health and disease susceptibility.
    • Findings highlight the critical role of early environmental factors in programming lifelong health outcomes.