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Updated: Jun 22, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Tumor angiogenesis in melanoma

Alexander G Marneros1

  • 1Cutaneous Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA. alexander_marneros@yahoo.com

Hematology/Oncology Clinics of North America
|May 26, 2009
PubMed

Insights

Combining angiogenesis inhibitors with other treatments shows promise for metastatic melanoma. Understanding melanoma tumor angiogenesis mechanisms is crucial for targeted antiangiogenic therapies.

Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • Metastatic melanoma treatment is an active area of clinical research.
  • Angiogenesis inhibitors are being investigated for their therapeutic potential.

Purpose of the Study:

  • To highlight the importance of understanding melanoma tumor angiogenesis.
  • To emphasize the need for combination therapies in metastatic melanoma treatment.

Main Methods:

  • Review of current clinical studies on angiogenesis inhibitors in metastatic melanoma.
  • Analysis of the mechanisms underlying melanoma tumor angiogenesis.

Main Results:

  • Combination therapy (angiogenesis inhibitors + cytotoxic agents/other modalities) appears more effective than monotherapy.
  • A deep understanding of melanoma angiogenesis is essential for targeted antiangiogenic strategies.

Conclusions:

  • Combined therapeutic approaches are likely to yield greater clinical benefit for metastatic melanoma patients.
  • Targeted antiangiogenic treatment requires comprehensive knowledge of tumor angiogenesis mechanisms.

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