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Neuroprotection: extrapolating from neurologic diseases to the eye
Helen V Danesh-Meyer1, Leonard A Levin
1Department of Ophthalmology, University of Auckland Medical School, Auckland, New Zealand. helendm@gmail.com
Purpose:
To review the current status of neuroprotection in ophthalmic disease.
Design:
Perspective.
Methods:
Published and unpublished data on neuroprotection in neurologic and ophthalmologic diseases were reviewed and interpreted.
Results:
Almost all clinical studies of neuroprotection in neurologic and ophthalmologic disease so far have failed to show efficacy, despite encouraging preclinical studies.
Conclusions:
Achievement of consensus on how to design and execute translational research in neuroprotection in ophthalmic disease would optimize the use of resources and would hasten the development and approval of effective neuroprotective agents.
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