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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New clerodane diterpenoids from Casearia sylvestris
Wei Wang1, Zulfiqar Ali, Xing-Cong Li
1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS 38677, USA.
Abstract:
Two new clerodane diterpenoids 2 beta-methoxy-cleroda-3,13-dien-18-carboxy-15,16-olide (1) and 15 xi-methoxy-cleroda-3,12-dien-18-carboxy-15,16-olide (2) and one new nitrogen-containing clerodane diterpenoid 15-oxo-echinophyllin A (3), along with six known compounds, namely, echinophyllin A, (-)-patagonic acid, tyrosol, oplopanone, 4-hydroxy-4-methyl-2-[(1R)-1-(1-methylethyl)-4-oxopentyl]-2-cyclohexen-1-one and 1 beta,6 alpha-dihydroxy-eudesman-4(15)-ene were isolated from the leaves of Casearia sylvestris. Their structures were determined by extensive NMR techniques.
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