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Published on: November 18, 2022
An innovative floating gastro retentive dosage system: formulation and in vitro evaluation
C Sauzet1, M Claeys-Bruno, M Nicolas
1Université de la Méditerranée, EA 4263, Faculté de Pharmacie, Marseille Laboratoire de Pharmacie galénique, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
International Journal of Pharmaceutics
|May 26, 2009
Summary
Researchers developed a novel floating gastro retentive dosage form (GRDF) using a unique hydrophobic excipient. This innovative formulation achieves high active pharmaceutical ingredient (API) concentration and sustained drug delivery for improved gastroretentive drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Gastro retentive dosage forms (GRDFs) are crucial for enhancing drug efficacy by prolonging gastric residence time.
- Existing GRDF technologies have limitations, necessitating the development of innovative solutions.
- High active pharmaceutical ingredient (API) concentration in GRDFs is often challenging to achieve.
Purpose of the Study:
- To develop an innovative floating gastro retentive dosage form (GRDF) with a high API concentration.
- To optimize the formulation for enhanced buoyancy and drug release characteristics.
- To establish a novel manufacturing process for the developed GRDF.
Main Methods:
- Utilized a state-of-the-art wet granulation process to manufacture the GRDF.
- Employed a hydrophobic dusty powder excipient to achieve low density and high API loading.
- Conducted an experimental design with discrete and mixture variables to optimize formulation parameters.
- Developed a custom apparatus for measuring the apparent density of floating tablets.
Main Results:
- Successfully developed a low-density GRDF with a high concentration of the active pharmaceutical ingredient (API).
- Optimized formulation parameters through experimental design to achieve desired buoyancy and API loading.
- Characterized the GRDF for key parameters including apparent density, buoyancy, porosity, and in vitro dissolution profiles.
Conclusions:
- The developed wet granulation technique and hydrophobic excipient enable the creation of innovative floating gastro retentive dosage forms.
- The optimized GRDF exhibits desirable properties for gastroretentive drug delivery, including high API concentration and buoyancy.
- This study presents a promising approach for advancing gastro retentive drug delivery technologies.
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