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Updated: Jun 22, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants
P Srinarong1, J H Faber, M R Visser
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. P.srinarong@rug.nl
Abstract:
In this study, it was shown that the incorporation of superdisintegrants in solid dispersion tablets containing a high drug load can strongly enhance the dissolution rate of the highly lipophilic drug fenofibrate. In addition, the dissolution rate was more increased when the superdisintegrant was incorporated in the drug containing solid dispersions than when it was physically mixed with the solid dispersions. The dissolution rate enhancement strongly depended on the type of superdisintegrants and increased in the order Polyplasdone XL-10
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