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Hyperglycemia

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Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...

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Updated: Jun 22, 2026

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Published on: January 26, 2024

Stress hyperglycaemia.

Kathleen M Dungan¹, Susan S Braithwaite, Jean-Charles Preiser

¹The Ohio State University, Columbus, OH 43210-1296, USA. kathleen.dungan@osumc.edu

Lancet (London, England)

|May 26, 2009

Summary

This summary is machine-generated.

Hospitalized patients need individualized blood sugar management. Stress hyperglycemia, often overlooked in patients with or without diabetes, may pose higher risks than pre-existing diabetes, requiring specific classification and treatment strategies.

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Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

Area of Science:

Internal Medicine
Endocrinology
Critical Care Medicine

Background:

Tight glycemic control trials in hospitalized patients yield variable results based on population and disease.
Pre-existing diabetes is a known risk factor for hyperglycemia, but stress hyperglycemia is also prevalent.
Stress hyperglycemia, defined as transient hyperglycemia during acute illness, can occur in patients with or without known diabetes.

Purpose of the Study:

To classify stress hyperglycemia in hospital inpatients.
To elucidate the mechanisms of harm associated with stress hyperglycemia.
To outline management strategies for stress hyperglycemia.

Main Methods:

Review of existing literature on hyperglycemia in hospital inpatients.
Analysis of studies comparing outcomes in patients with and without diabetes.
Examination of definitions and diagnostic criteria for stress hyperglycemia.

Main Results:

Stress hyperglycemia is often overlooked, particularly in patients with pre-existing diabetes.
Patients experiencing stress hyperglycemia may face greater risks than those with established diabetes.
Distinguishing between stress and pre-existing hyperglycemia is crucial for appropriate patient management.

Conclusions:

Individualized glycemic management is essential for diverse hospital inpatient populations.
Accurate classification of stress hyperglycemia is needed to identify at-risk patients.
Understanding the unique risks and management of stress hyperglycemia can improve patient outcomes.