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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

Testosterone therapy in men

Aikaterini Theodoraki1, Pierre-Marc Bouloux

  • 1Centre for Neuroendocrinology, Royal Free Campus, University College Medical School, Rowland Hill Street, London NW3 2PF, UK. k_theodoraki@yahoo.gr

Menopause International
|May 26, 2009
PubMed

Insights

Testosterone deficiency (hypogonadism) causes various symptoms corrected by replacement therapy. Further research is needed on testosterone replacement

Area of Science:

  • Endocrinology and Men's Health
  • Molecular Biology

Background:

  • Androgens, like testosterone, are crucial for numerous physiological functions.
  • Testosterone deficiency (hypogonadism) in men leads to diverse symptoms and signs.
  • The impact of hypogonadism varies with age at onset.

Purpose of the Study:

  • To review the physiological roles of androgens and testosterone.
  • To discuss the clinical implications of hypogonadism and its management.
  • To explore emerging therapeutic strategies targeting the androgen receptor.

Main Methods:

  • Review of recent studies on testosterone's relation to aging, metabolic syndrome, type 2 diabetes, obesity, and survival.
  • Examination of molecular targets of testosterone.
  • Analysis of ongoing clinical trials for selective androgen receptor modulators (SARMs).

Main Results:

  • Testosterone replacement therapy corrects hypogonadism symptoms.
  • Further large-scale, long-term studies are required to clarify testosterone replacement therapy's effects on aging and metabolic conditions.
  • Selective androgen receptor modulators (SARMs) are under clinical investigation as potential therapeutics.

Conclusions:

  • Testosterone plays a vital role in male physiology and health.
  • Close monitoring is advised during testosterone replacement therapy.
  • Targeting the androgen receptor with agents like SARMs represents a promising area for future therapeutic development.

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