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Updated: Jun 22, 2026
07:32
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
Published on: March 6, 2018
Impact of adiposity on immunological parameters
Cristiane Martins Moulin1, Ivo Marguti, Jean Pierre S Peron
1Departamento de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar 255, São Paulo, SP, Brazil. crismoulin@yahoo.com.br
Arquivos Brasileiros De Endocrinologia E Metabologia
|May 26, 2009
Summary
Obesity impairs immune responses, increasing infection and cancer risks. Weight loss may alter immune function, but long-term studies are needed to confirm benefits for obese individuals.
Area of Science:
- Immunology
- Endocrinology
- Metabolic Disorders
Background:
- Excess adiposity in obesity is linked to compromised immune responses.
- Obesity correlates with increased susceptibility to infections and certain cancers.
- Nutritional, metabolic, and endocrine factors contribute to obesity-related immunological alterations.
Purpose of the Study:
- To review the impact of obesity on immune function.
- To explore the role of adipose tissue in immune regulation.
- To examine how weight reduction strategies affect immune responses in obese individuals.
Main Methods:
- Literature review of studies on human and animal models of obesity.
- Analysis of research on the immunological effects of nutritional, metabolic, and endocrine factors.
- Evaluation of evidence regarding weight loss interventions and immune function.
Main Results:
- Obesity is associated with impaired immune responses.
- Adipose tissue actively produces immunomodulatory substances.
- Weight reduction strategies may influence immune function, but require further investigation.
Conclusions:
- Obesity significantly impacts the immune system, increasing disease risk.
- Further long-term research is essential to determine if weight loss interventions improve immune control of infections and tumors in obese populations.
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