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Updated: Aug 8, 2026

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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Summary
Sclerosing injections for great saphenous veins show over 90% success. Small vein calibre correlates with better results, while thrombosis can lead to recurrence after sclerotherapy.
Area of Science:
- Vascular Surgery
- Phlebology
- Medical Imaging
Background:
- Great saphenous vein (GSV) incompetence is a common condition.
- Sclerotherapy is a widely used treatment for varicose veins.
- Understanding the mechanism of sclerosis is crucial for optimizing treatment outcomes.
Purpose of the Study:
- To analyze the mechanism of sclerosis following sclerosing injections in the great saphenous veins.
- To investigate the relationship between vein calibre and treatment outcomes.
- To identify factors contributing to recurrence after sclerotherapy.
Main Methods:
- Prospective study involving 309 great saphenous veins.
- Doppler and ultrasonography used to analyze the sclerosis mechanism.
- Sclerosing injections administered within 50mm of the sapheno-femoral junction over five sessions.
Main Results:
- A strong correlation was found between small vein calibre and favorable treatment results.
- Recurrence by early repermeation was often linked to sclerosing-induced thrombosis.
- Over 90% favorable responses were observed after a 15.7-month follow-up period.
Conclusions:
- Sclerosing injection therapy is highly effective for great saphenous vein treatment.
- Vein calibre and thrombosis are key factors influencing sclerotherapy outcomes.
- Further analysis of treatment parameters may refine management strategies for this condition.
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