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Updated: Jun 22, 2026
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
[Von Willebrand's disease and anesthesia.]
Fabiano Timbó Barbosa1, Rafael Martins da Cunha, Luciano Timbó Barbosa
1Centro de Ensino Superior de Maceió.
Revista Brasileira De Anestesiologia
|May 26, 2009
Summary
Von Willebrand's disease, the most common inherited bleeding disorder, requires careful perioperative management. Proper classification and treatment, including desmopressin and factor replacement, are crucial for successful anesthesia in affected patients.
Area of Science:
- Genetics and Molecular Biology
- Hematology
Context:
- Von Willebrand's disease (VWD) is a common inherited bleeding disorder caused by genetic mutations.
- It presents with diverse clinical manifestations due to qualitative and quantitative deficiencies in von Willebrand factor.
- VWD is characterized by platelet dysfunction and reduced Factor VIII levels.
Purpose:
- To review the perioperative care strategies for patients diagnosed with Von Willebrand's disease.
- To discuss the physiopathology, classification, diagnosis, and treatment of VWD.
- To highlight essential considerations for anesthetic management in VWD patients.
Summary:
- VWD is the most prevalent hereditary coagulopathy, often underdiagnosed due to its complexity.
- Accurate classification of VWD subtypes is essential for effective management.
- Perioperative care involves understanding the disease's genetic basis and clinical spectrum.
Impact:
- Optimized perioperative management can significantly improve outcomes for patients with VWD.
- Enhanced understanding of VWD facilitates timely diagnosis and appropriate treatment.
- Successful anesthesia in VWD patients relies on precise classification and targeted therapeutic interventions.
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