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Asymmetric Lipid Bilayer01:35

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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[Primary bilateral lipid keratopathy].

M Castro-Rebollo1, M A Montes-Mollón, C Pérez-Rico

  • 1Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain. mariarebollo@yahoo.es

Archivos De La Sociedad Espanola De Oftalmologia
|May 26, 2009
PubMed
Summary
This summary is machine-generated.

This case report details a rare condition of primary lipid keratopathy, characterized by slow-progressing, bilateral corneal lipid deposits. The findings highlight the importance of differentiating this from other lipid disorders.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Ocular Surface Disease

Background:

  • Primary lipid keratopathy is a rare, non-inflammatory corneal deposition disorder.
  • It is characterized by lipid accumulation in the corneal stroma.
  • Diagnosis requires excluding systemic or secondary causes of corneal lipid deposition.

Observation:

  • A 45-year-old woman presented with chronic bilateral eye irritation and photophobia.
  • Slit-lamp examination revealed bilateral, peripheral, yellow-whitish stromal deposits.
  • Visual acuity was moderately impaired due to the progressive nature of the deposits.

Findings:

  • The corneal deposits were symmetric and bilateral.
  • Absence of corneal vascularization and other ocular pathologies was noted.
  • No evidence of systemic lipoprotein disorder was found, supporting a primary diagnosis.

Implications:

  • This case underscores the clinical presentation of primary lipid keratopathy.
  • Accurate diagnosis is crucial to differentiate from other corneal lipid disorders.
  • Understanding the etiology aids in appropriate patient management and prognosis.