Related Experiment Video
Updated: Jun 22, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Ospemifene use in postmenopausal women
Luigi Gennari1, Daniela Merlotti, Fabrizio Valleggi
1Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, Policlinico Le Scotte, Siena, Italy. gennari@unisi.it
Ospemifene effectively treats vulvar and vaginal atrophy in postmenopausal women, showing significant improvement over lubricants with a favorable safety profile. Further research is needed to confirm bone and breast benefits.
Area of Science:
- Pharmacology
- Gynecology
- Menopause Research
Background:
- Selective estrogen receptor modulators (SERMs) are versatile drugs for menopausal conditions like cancer and osteoporosis.
- Current SERMs have side effects including thromboembolic disorders and menopausal symptoms.
- Ospemifene is a novel SERM developed for vulvar and vaginal atrophy.
Purpose of the Study:
- To review clinical trials of ospemifene for vulvar and vaginal atrophy.
- Literature search focused on 'ospemifene' and 'SERMs'.
Main Methods:
- Review of clinical trial data for ospemifene.
- Analysis of Phase III study results.
Main Results:
- Ospemifene 60 mg/day significantly improved vulvar and vaginal atrophy symptoms compared to non-hormonal vaginal lubricant.
- Ospemifene demonstrated good tolerability with minimal side effects.
- Preclinical studies indicated potential benefits for bone and breast health.
Conclusions:
- Ospemifene is a promising new SERM for treating vulvar and vaginal atrophy in postmenopausal women.
- Its safety profile appears favorable.
- Clinical confirmation of bone and breast benefits is required to fully establish its therapeutic potential.
More Related Videos
07:20Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
06:00Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
Related Concept Videos
01:28Menopause
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...