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Updated: Feb 10, 2026

Author Spotlight: Optimizing Growth Factors for Production of Biotechnologically Relevant Secondary Metabolites
Published on: October 25, 2024
Factors effecting expression of vaccines in microalgae
Raymond Surzycki1, Katie Greenham, Kaoru Kitayama
1PhycoBiologics Inc, Indianapolis IN, Bloomington, IN 47401, USA.
Abstract:
PhycoBiologics is developing an oral vaccine delivery system using vaccines expressed in the chloroplast of microalgae. Despite many advances in plastid transformation technology, levels of expression remain inconsistent. We have concluded that the main factors affecting the level of recombinant protein expression in the chloroplast of Chlamydomonas are: codon optimization, protease activity, protein toxicity and transformation-associated genotypic modification.
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