Radical cystectomy for bladder cancer: A single center experience
Narmada P Gupta1, Surendra B Kolla, Amlesh Seth
1Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
Summary
Radical cystectomy with pelvic lymphadenectomy offers good survival for bladder cancer patients. This procedure shows a low rate of local recurrence, highlighting its effectiveness for invasive transitional cell carcinoma.
Area of Science:
- Urology
- Oncology
- Surgical Oncology
Background:
- Transitional cell carcinoma (TCC) is the most common type of bladder cancer.
- Radical cystectomy (RC) with pelvic lymphadenectomy is a standard treatment for invasive bladder cancer.
Purpose of the Study:
- To evaluate the long-term clinical outcomes of radical cystectomy and pelvic lymphadenectomy in patients with transitional cell carcinoma of the bladder.
- To assess survival rates, recurrence patterns, and complications associated with this surgical approach.
Main Methods:
- A retrospective analysis of 432 patients with primary transitional cell carcinoma of the bladder who underwent radical cystectomy and bilateral pelvic lymphadenectomy with curative intent.
- Data collected included clinical course, pathological characteristics, perioperative outcomes, and long-term survival and recurrence data.
- Median follow-up was 62 months.
Main Results:
- The study reported 30 perioperative deaths (6.9%) and 111 early complications (25.7%).
- Five-year recurrence-free survival (RFS) and overall survival (OAS) were 66% and 62%, respectively, with 10-year rates of 62% and 40%.
- Pathological stage and lymph node status significantly impacted RFS and OAS (P < 0.001). Recurrence occurred in 33.5% of patients, with 72.4% being distant recurrences.
Conclusions:
- Radical cystectomy with pelvic lymphadenectomy provides favorable survival outcomes for patients with invasive bladder cancer.
- The procedure is associated with a low incidence of local pelvic recurrence, suggesting its efficacy in managing advanced bladder tumors.
