Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Penis01:29

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergy between oral PDE5 inhibitors and topically applied nitric oxide microparticles on the erectile response in a rat model of cavernous nerve injury.

International journal of impotence research·2025
Same author

Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases.

Therapeutic advances in urology·2022
Same author

Gene Therapy for Overactive Bladder: A Review of BK-Channel α-Subunit Gene Transfer.

Therapeutics and clinical risk management·2021
Same author

Topically delivered nitric oxide acts synergistically with an orally administered PDE5 inhibitor in eliciting an erectile response in a rat model of radical prostatectomy.

International journal of impotence research·2021
Same author

Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.

JCI insight·2021
Same author

Role of opiorphin genes in prostate cancer growth and progression.

Future oncology (London, England)·2021

Related Experiment Video

Updated: Jun 22, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Markers of erectile dysfunction.

Kelvin P Davies1, Arnold Melman

  • 1Institute of Smooth Muscle Biology and Department of Urology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY10461, USA.

Indian Journal of Urology : IJU : Journal of the Urological Society of India
|May 27, 2009
PubMed
Summary
This summary is machine-generated.

Identifying genetic markers for organic erectile dysfunction (ED) is crucial. Such markers could predict cardiovascular disease and diabetes, and differentiate ED causes for better treatment and reimbursement.

Keywords:
Biomarkererectile dysfunction

Related Experiment Videos

Last Updated: Jun 22, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Cardiology
  • Genetics

Background:

  • Oral pharmacotherapy has reduced focus on identifying organic erectile dysfunction (ED) markers.
  • ED's multifactorial nature and correlation with overall male health, including cardiovascular disease (CVD) and diabetes, necessitate renewed interest in organic ED markers.
  • Distinguishing organic ED from psychogenic ED is important for patient management and insurance reimbursement.

Purpose of the Study:

  • To review the importance of identifying biomarkers for organic erectile dysfunction (ED).
  • To discuss recent advancements in identifying potential genetic markers for ED in human patients.
  • To highlight the potential of ED markers in predicting comorbidities like CVD and diabetes.

Main Methods:

  • This is a review article, discussing existing literature and research findings.
  • Focuses on the significance of genetic markers in differentiating organic ED.
  • Examines the correlation between ED and other chronic health conditions.

Main Results:

  • ED is a significant indicator of underlying health issues, including cardiovascular disease and diabetes.
  • The identification of specific genetic markers could aid in diagnosing organic ED.
  • Potential markers may offer objective measures for ED severity and treatment efficacy.

Conclusions:

  • Identifying reliable markers for organic ED is essential for accurate diagnosis and patient management.
  • Such markers can serve as early predictors for serious health conditions like CVD and diabetes.
  • Further research into genetic markers holds promise for improving ED diagnostics and treatment strategies.