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Related Experiment Video

Updated: Jun 22, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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[Excessive sweating and hypothermia after spinal morphine: case report.].

Gustavo Prosperi Bicalho¹, Carlos Henrique Viana Castro, Marcos Guilherme Cunha Cruvinel

¹Hospital Life Center.

Revista Brasileira De Anestesiologia

|May 27, 2009

Summary

Spinal morphine can disrupt body temperature regulation, causing hypothermia and sweating. This case highlights potential hypothalamic effects beyond typical anesthesia-induced heat loss.

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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

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Published on: November 9, 2016

Area of Science:

Anesthesiology
Neuroscience
Thermoregulation

Context:

Perioperative hypothermia is a common complication of anesthesia and surgery.
Neuraxial blocks, like spinal anesthesia, can alter body temperature regulation.
Morphine, when administered intrathecally, may have direct effects on central thermoregulatory mechanisms.

Purpose:

To report an unusual case of body heat balance disturbance associated with spinal morphine.
To explore potential direct effects of spinal morphine on hypothalamic temperature control centers.

Summary:

A 44-year-old female patient developed excessive sweating, mild sleepiness, and hypothermia (35.2°C) 3.5 hours after spinal anesthesia with bupivacaine and morphine for hysterectomy.
The patient's temperature remained below 36°C for 60 minutes before normalizing to 36.2°C after 90 minutes, with complete symptom remission.
This event suggests that spinal morphine may directly impact the hypothalamus's temperature control, in addition to known mechanisms of heat loss during neuraxial blockade.

Impact:

This case suggests a need to consider direct central thermoregulatory effects of intrathecal opioids.
Understanding these effects can help in managing perioperative temperature dysregulation.
Further research may elucidate the precise mechanisms by which spinal morphine influences hypothalamic function.