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Updated: Jun 22, 2026

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
Published on: March 14, 2020
Liver architecture, cell function, and disease
Hiromi Ishibashi1, Minoru Nakamura, Atsumasa Komori
1Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. hiishibashi-gi@umin.ac.jp
Abstract:
The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.
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