Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and characterization of monoclonal antibodies to spring viraemia of carp virus.

Veterinary immunology and immunopathology·2008

Same author

Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ]bis(4-methyl)-benzenesulfonamide found in virtual screening.

Acta pharmacologica Sinica·2008

Same author

Cloning and characterization of an rRNA methyltransferase from Sorangium cellulosum.

Biochemical and biophysical research communications·2008

Same author

Reconstruction of anophthalmic orbits and contracted eye sockets with microvascular radial forearm free flaps.

Ophthalmic plastic and reconstructive surgery·2008

Same author

Using low intensity ultrasound to improve the efficiency of biological phosphorus removal.

Ultrasonics sonochemistry·2008

Same author

[Study on the spectrum of the flocculent conformation of polymer ferric sulfate flocculants].

Guang pu xue yu guang pu fen xi = Guang pu·2008

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Thrombotic storm in Kimura disease.

Hong Liu¹, Samer Z Al-Quran, Richard Lottenberg

¹Department of Medicine, Division of Hematology/Oncology, University of Florida College of Medicine, P.O. Box 100277, Gainesville, FL 32610-0296, USA.

Journal of Thrombosis and Thrombolysis

|May 27, 2009

Summary

This summary is machine-generated.

Kimura disease, typically benign, can cause severe "thrombotic storm" with visceral venous thromboses. This case shows hypercoagulability linked to this eosinophilic disorder, managed with warfarin.

More Related Videos

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Published on: June 2, 2016

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Related Experiment Videos

Last Updated: Jun 22, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique

Published on: June 2, 2016

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Area of Science:

Immunology
Hematology
Pathology

Background:

Kimura disease is a chronic inflammatory condition common in Asians, characterized by angiolymphoid proliferation, eosinophil infiltration, eosinophilia, and elevated IgE.
The disease is generally considered indolent and benign in its clinical course.

Observation:

A patient with Kimura disease presented with life-threatening visceral venous thromboses, a condition termed 'thrombotic storm'.
Extensive evaluation excluded inherited thrombophilia and other acquired causes of visceral venous thromboembolism.

Findings:

The patient experienced a major thrombotic event despite no identifiable thrombophilia.
Continuous warfarin therapy over four years prevented recurrent thrombotic events, even with persistent eosinophilia and Kimura disease manifestations.

Implications:

This case suggests a potential link between Kimura disease and hypercoagulability, challenging the notion of its benign course.
Highlights the importance of considering hypercoagulability in patients with Kimura disease and thrombotic events.
Suggests anticoagulation as a potential management strategy for thrombotic complications in Kimura disease.