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Updated: Jun 22, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Role of heparanase-1 in gastric carcinoma invasion
Xu Yingying1, Zhang Yong, Wang Zhenning
1Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang, P.R. China.
Purpose:
The heparan sulfate-degrading endoglycosidase may mediate tumor invasion and metastasis. It is known that heparanase-1 (HPA-1) plays an important role in cleaving heparan sulfate. In this study we investigated its potential role in gastric carcinoma malignant behaviour.
Methods:
To assess the role of HPA-1, we suppressed its expression using small interfering RNA (siRNA). The human heparanase-1 specific siRNA was transfected to the human gastric carcinoma cell line SGC7901. The effect of gene silencing was assessed by Real-Time PCR and Western Blot. The invasion potential of the cells was evaluated using an in vitro cell invasion model system.
Results:
The HPA-1 specific siRNA significantly suppressed expression of heparanase-1 in SGC7901 cells. Invasion after RNAi treatment through membranes in a model system was significantly decreased.
Conclusion:
HPA-1 facilitates gastric carcinoma invasion by up-regulating endoglycosidase activity in tumor cells.
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