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A new model for the assay of comedolytic activity
1Secteur de Dermatologie Expérimentale, Laboratoire de Pathologie Expérimentale, Faculté Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris.
Abstract:
Synopsis An experimental model using the 'Rhino' hairless mouse has been developed for screening comedolytic agents. The skin of this animal presents a high density of spontaneous comedos which appear in histological slices as cystic formations with a large diameter (D) and an open narrow neck (d). The ratio d/D expresses the 'comedo profile'. Statistical evaluation of this value by standardized measurement allows the quantification of comedolytic activity of pharmacological agents.
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