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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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Microorganisms are routinely cultured in the laboratory using various techniques to isolate, grow, and quantify them for further study. These methods rely on inoculating microorganisms into a suitable growth medium under aseptic conditions to prevent contamination. Depending on the objective, inoculation can involve direct transfer or the use of diluted bacterial suspensions as the inoculum.Streak-Plate Method for IsolationThe streak-plate method is a common technique for obtaining pure...

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Related Experiment Video

Updated: Jun 22, 2026

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

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Published on: February 6, 2020

Studies on isolated corneocytes.

R Marks1, S Nicholls, C S King

  • 1Department of Medicine, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN.

International Journal of Cosmetic Science
|May 28, 2009
PubMed
Summary
This summary is machine-generated.

This study investigates corneocyte dimensions and their impact on stratum corneum function. Changes in corneocyte size with age, site, and topical applications were analyzed, alongside desquamation rates.

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Area of Science:

  • Dermatology
  • Skin Biology
  • Biophysics

Background:

  • The stratum corneum's barrier function relies on its cellular components.
  • Corneocyte dimensions are critical for maintaining skin integrity and function.

Purpose of the Study:

  • To investigate the relationship between corneocyte dimensions and stratum corneum function.
  • To document changes in corneocyte size related to aging, anatomical site, and topical treatments.
  • To assess desquamation rates and their correlation with corneocyte characteristics.

Main Methods:

  • Development and application of a technique to measure corneocyte thickness.
  • Quantification of corneocyte dimensions across different ages and skin sites.
  • Evaluation of corneocyte changes following topical product application.
  • Measurement of passive and stimulated corneocyte desquamation rates.
  • Scanning and transmission electron microscopy for detailed corneocyte morphology.
  • Preliminary immunological studies on corneocyte and stratum corneum biochemistry.

Main Results:

  • Corneocyte dimensions vary significantly with age and anatomical location.
  • Topical applications induce measurable alterations in corneocyte size and structure.
  • Desquamation rates are influenced by corneocyte characteristics and external stimuli.
  • Electron microscopy provides detailed insights into corneocyte ultrastructure.

Conclusions:

  • Corneocyte dimensions are a key determinant of stratum corneum function.
  • Understanding these dimensional changes is crucial for evaluating skin health and the efficacy of dermatological treatments.
  • Further research into corneocyte biochemistry may reveal new therapeutic targets.