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Related Concept Videos

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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
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Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Related Experiment Video

Updated: Jun 22, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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Published on: March 10, 2015

[Megacolon and arthritis].

Anna Bazsó1, Krisztina Sevcic, Ilonka Orbán

  • 1Országos Reumatológiai és Fizioterápiás Intézet Budapest Frankel Leó u. 38-40. 1023. bazsoanna@yahoo.com

Orvosi Hetilap
|May 28, 2009
PubMed
Summary

This report details four cases of megacolon and seronegative spondyloarthritis. Surgical intervention for megacolon led to arthritis remission in one patient, highlighting a potential link.

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Immunology

Background:

  • Megacolon, a condition characterized by an enlarged colon, can present with various extraintestinal manifestations.
  • Seronegative spondyloarthritis encompasses a group of inflammatory joint diseases that lack rheumatoid factor.
  • The co-occurrence of megacolon and seronegative spondyloarthritis is rare, with limited understanding of its etiology.

Observation:

  • Four patients presented with both significant megacolon and symptoms of seronegative spondyloarthritis.
  • Physical examination revealed a palpable mass consistent with fecal impaction (scybala) in the left iliac region in all cases.
  • The underlying cause for this association was identified in only one of the four reported cases.

Findings:

  • The musculoskeletal manifestations were consistent with the spectrum of seronegative spondyloarthritis.

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Last Updated: Jun 22, 2026

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  • Surgical correction of the colonic obstruction resulted in complete resolution of arthritis symptoms in one patient.
  • In the remaining three patients, persistent chronic constipation and recurrent arthritis flares were observed post-operatively.

    • Implications:

    • This case series suggests a potential pathogenic link between colonic dysfunction and seronegative spondyloarthritis.
    • Further research is warranted to elucidate the mechanisms underlying this association.
    • Identifying and managing colonic issues may be crucial for patients with unexplained seronegative spondyloarthritis.