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Mouse models of altered protein kinase A signaling

Lawrence S Kirschner1, Zhirong Yin, Georgette N Jones

  • 1Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, 420 West 12th Avenue, TMRF 544, Columbus, Ohio 43210, USA. lawrence.kirschner@osumc.edu

Endocrine-Related Cancer
|May 28, 2009
PubMed

Insights

Mouse models reveal the complex role of protein kinase A (PKA) signaling in endocrine health and disease. This research clarifies PKA

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Genetics

Background:

  • The cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) pathway is a fundamental signaling system with roles in various physiological processes.
  • Despite being the first characterized mammalian second messenger system, many aspects of cAMP-PKA signaling remain unclear.
  • Recent evidence links PKA signaling to endocrine tumorigenesis, prompting renewed investigation into its physiological functions.

Purpose of the Study:

  • To review current knowledge on the physiological roles of the PKA signaling system.
  • To summarize findings from mouse models that have genetically manipulated components of the PKA pathway.
  • To elucidate the involvement of PKA signaling in endocrine function and disease.

Main Methods:

  • Review of existing literature on PKA signaling and mouse models.
  • Analysis of data from genetically engineered mouse models targeting the PKA pathway.
  • Synthesis of findings to understand PKA's role in physiology and disease.

Main Results:

  • Mouse models have illuminated the intricate and nuanced functions of PKA signaling.
  • Targeted genetic studies in mice have provided insights into PKA's involvement in endocrine regulation.
  • These models demonstrate PKA's complex role in both normal physiology and pathological conditions like cancer.

Conclusions:

  • Mouse models are crucial for dissecting the physiological roles of PKA signaling.
  • Understanding PKA's complexity is key to exploring its therapeutic potential.
  • Future research using these models may lead to strategies for modulating PKA for therapeutic benefit in endocrine diseases.

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