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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

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Related Experiment Video

Updated: Jun 22, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Proteomics in thyroid tumor research.

Kerstin Krause1, Beate Jessnitzer, Dagmar Fuhrer

  • 1Department of Internal Medicine, Division of Endocrinology and Diabetology, University of Leipzig, Ph.-Rosenthal-Strasse 27, Leipzig, Germany. Kerstin.Krause@medizin.uni-leipzig.de

The Journal of Clinical Endocrinology and Metabolism
|May 28, 2009
PubMed
Summary
This summary is machine-generated.

Proteomics offers a powerful approach to understanding thyroid cancer biology. This review explores proteomics methods and findings in thyroid tumor research, highlighting its potential for improved diagnosis and targeted therapies.

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Related Experiment Videos

Last Updated: Jun 22, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • OMICS technologies enable identification of molecular signatures and pathways in tumorigenesis.
  • Proteomics is emerging as a key tool to reflect tumor biology and discover cancer biomarkers.
  • Biomarkers are crucial for cancer diagnosis, prognosis, and targeted treatment strategies.

Purpose of the Study:

  • To review the application of proteomics in thyroid tumor research.
  • To provide an overview of protein expression profiling methods relevant to thyroid proteomics.
  • To discuss the specific requirements and challenges in thyroid proteomics.

Main Methods:

  • Overview of various protein expression profiling techniques.
  • Analysis of published proteomics studies on human thyroid tumors.
  • Integration of proteomics with mRNA expression profiling and biochemical methods.

Main Results:

  • Summary of findings from existing proteomics studies on thyroid tumors.
  • Identification of challenges and requirements specific to thyroid proteomics.
  • Demonstration of proteomics' contribution to understanding thyroid tumorigenesis.

Conclusions:

  • Proteomics is a valuable tool for advancing thyroid tumor research.
  • Combining proteomics with other methods enhances understanding of thyroid cancer.
  • Future applications of thyroid proteomics may lead to novel therapeutic strategies.