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Related Experiment Video

Updated: Jun 22, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy.

L R Rosenberger¹, J Zeck, M M Berl

¹Department of Neuroscience, Children's National Medical Center, 111 Michigan Ave. NW, Washington, DC 20010, USA.

|May 28, 2009

Summary

Patients with left hemisphere epilepsy showed right hemisphere language activation, suggesting interhemispheric reorganization. Little evidence for intrahemispheric reorganization was found in these patients.

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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Area of Science:

Neuroscience
Neurology
Cognitive Science

Background:

Localization-related epilepsy involves focal brain abnormalities.
Understanding brain reorganization is crucial for epilepsy management.

Purpose of the Study:

Investigate interhemispheric and intrahemispheric reorganization in epilepsy.
Examine language network plasticity in patients with left hemispheric epilepsy.

Main Methods:

Functional MRI (fMRI) was used to study 50 epilepsy patients and 20 controls.
An auditory-based word definition task assessed language processing.
Asymmetry Index (AI) categorized patients into left (LL) or atypical (AL) language dominance.

Main Results:

Patients frequently showed activation in right hemisphere language homologues.
Atypical language (AL) groups exhibited activation in homologous right regions.
Left language (LL) patients showed subtle, variable shifts in left hemisphere activation.

Conclusions:

Right hemisphere regions serve as functional homologues for Broca's and Wernicke's areas in epilepsy.
Limited evidence supports intrahemispheric reorganization in left hemisphere epilepsy patients with preserved left dominance.